Search results for "model [interaction]"

Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells

2013

International audience; Bleomycin (BLM) is an anticancer drug currently used for the treatment of testis cancer and Hodgkin lymphoma. This drug triggers cancer cell death via its capacity to generate radical oxygen species (ROS). However, the putative contribution of anticancer immune responses to the efficacy of BLM has not been evaluated. We make here the observation that BLM induces immunogenic cell death. In particular, BLM is able to induce ROS-mediated reticulum stress and autophagy, which result in the surface exposure of chaperones, including calreticulin and ERp57, and liberation of HMBG1 and ATP. BLM induces anti-tumor immunity which relies on calreticulin, CD8(+) T cells and inte…

Regulatory T Cells and IL-10 Independently Counterregulate Cytotoxic T Lymphocyte Responses Induced by Transcutaneous Immunization

2011

Background: The imidazoquinoline derivate imiquimod induces inflammatory responses and protection against transplanted tumors when applied to the skin in combination with a cognate peptide epitope (transcutaneous immunization, TCI). Here we investigated the role of regulatory T cells (Treg) and the suppressive cytokine IL-10 in restricting TCI-induced cytotoxic T lymphocyte (CTL) responses. Methodology/Principal Findings: TCI was performed with an ointment containing the TLR7 agonist imiquimod and a CTL epitope was applied to the depilated back skin of C57BL/6 mice. Using specific antibodies and FoxP3-diphteria toxin receptor transgenic (DEREG) mice, we interrogated inhibiting factors after…

A murine model of cerebral cavernous malformations with acute hemorrhage

2022

Cavernomas are multi-lumen and blood-filled vascular malformations which form in the brain and the spinal cord. They lead to hemorrhage, epileptic seizures, neurological deficits, and paresthesia. An effective medical treatment is still lacking, and the available murine models for cavernomas have several limitations for preclinical studies. These include disease phenotypes that differ from human diseases, such as restriction of the lesions to the cerebellum, and absence of acute hemorrhage. Additional limitations of current murine models include rapid development of lesions, which are lethal before the first month of age. Here, we have characterized a murine model that recapitulates feature…

À la recherche des maillages communaux d'antan. Présentation du projet ANR COMMUNES et de quelques résultats préliminaires

2020

The COMMUNES project aims: 1) to produce the first H-GIS in the world providing annualised boundary data for all French municipalities from the Revolution to the present day. Each spatial unit will include population data and metrics of access to networks of transport; 2) to develop a multimodal model of transport to allow the dynamic analysis of the relationship between economic and demographic changes and accessibility from the end of the 18th century to the present day; 3) to represent and analyse on a very fine scale some key demographic and socio-economic phenomena. Our method for reconstructing historic administrative boundaries combines the study of historical and cartographic source…

Archetypal analysis: contributions for estimating boundary cases in multivariate accommodation problem

2013

[EN] The use of archetypal analysis is proposed in order to determine a set of representative cases that entail a certain percentage of the population, in the accommodation problem. A well-known anthropometric database has been used in order to compare our methodology with the common used PCA-approach, showing the advantages of our methodology: the level of accommodation is reached unlike the PCA approach, no more adjustments are necessary, the user can decide the number of archetypes to consider or leave the selection by a criterion. Unlike PCA, the objective of the archetypal analysis is obtaining extreme individuals, so it is the appropriate statistical technique for solving this type of…

Relationships between perceived emotions in music and music-induced movement

2012

Listening to music makes us move in various ways. Several factors can affect the characteristics of these movements, including individual factors and musical features. Additionally, music-induced movement may also be shaped by the emotional content of the music, since emotions are an important element of musical expression. This study investigates possible relationships between emotional characteristics of music and music-induced, quasi-spontaneous movement. We recorded music-induced movement of 60 individuals, and computationally extracted features from the movement data. Additionally, the emotional content of the stimuli was assessed in a perceptual experiment. A subsequent correlational …

Experimental Evolution in Viruses

2011

Experiments in which evolution takes place in real time can help us establish cause–effect relationships that are difficult to infer from the analysis of natural populations. The simplicity, rapid evolution and biomedical relevance of viruses make them a particularly interesting model system for experimental evolution. Bacterial, animal and plant viruses can be passaged under a variety of conditions, either in simple cell culture systems or in vivo to test population biology hypotheses, study the genetic basis of evolution, or predict evolutionary change in nature. Experimental evolution is a conceptually simple and flexible tool which allows us to address issues ranging from the molecular …

Nonzero |U_e3| from charged lepton corrections and the atmospheric neutrino mixing angle

2013

After the successful determination of the reactor neutrino mixing angle theta(13) not equal 0.16 not equal 0, a new feature suggested by the current neutrino oscillation data is a sizeable deviation of the atmospheric neutrino mixing angle theta(23) from pi/4. Using the fact that the neutrino mixing matrix U = (UeU nu)-U-dagger, where U-e and U-nu result from the diagonalisation of the charged lepton and neutrino mass matrices, and assuming that U-nu has a i) bimaximal (BM), H) tri-bimaximal (TBM) form, or else Hi) corresponds to the conservation of the lepton charge L' = L-e - L mu - L-tau (LC), we investigate quantitatively what are the minimal forms of U-e, in terms of angles and phases …

2015

Polyunsaturated fatty acids (PUFAs) are essential nutrients for animals and necessary for the normal functioning of the nervous system. A lack of PUFAs can result from the consumption of a deficient diet or genetic factors, which impact PUFA uptake and metabolism. Both can cause synaptic dysfunction, which is associated with numerous disorders. However, there is a knowledge gap linking these neuronal dysfunctions and their underlying molecular mechanisms. Because of its genetic manipulability and its easy, fast, and cheap breeding, Drosophila melanogaster has emerged as an excellent model organism for genetic screens, helping to identify the genetic bases of such events. As a first step tow…

Parameters analysis of FitzHugh-Nagumo model for a reliable simulation

2014

International audience; Derived from the pioneer ionic Hodgkin-Huxley model and due to its simplicity and richness from a point view of nonlinear dynamics, the FitzHugh-Nagumo model has been one of the most successful neuron / cardiac cell model. It exists many variations of the original FHN model. Though these FHN type models help to enrich the dynamics of the FHN model. The parameters used in these models are often in biased conditions. The related results would be questionable. So, in this study, the aim is to find the parameter thresholds for one of the commonly used FHN model in order to pride a better simulation environment. The results showed at first that inappropriate time step and…